http://en.wikipedia.org/wiki/Retinoblastoma_protein &
http://www.sciencemag.org/cgi/reprint/246/4936/1406.pdf
The discovery that two suppressor genes, RB and p53, are intimately involved in cell cycle regulation...
The RB protein forms complexes with SV40 T antigen, the transforming protein of SV40 virus (60); adenovirus ElA protein, which is required for adenovirus-induced cell transformation (61); and the E7 protein of human papilloma virus (HPV) (62), which is required for HPVinduced tumor formation.
